For the millions of Americans who are significantly overweight (more than 20 lbs. of excess body weight and/or a BMI [body mass index] greater than 27), there is simply no longer any way to deny the genetic link to being overweight. That's why ordinary diet pills and so-called "fat magnets" (if they work at all) so often fail to help the significantly overweight. The genetic link to being overweight also means that repeated diet failure and chronic overweight may not be your fault. Unless a weight-control compound addresses the genetic factor and helps you overcome your genetic predisposition to being overweight your attempts at weight loss become no more than an exercise in futility (and a waste of time and money).